ID/Version |
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Sequence description from provider |
RecName: Full=Izumo sperm-egg fusion protein 1 {ECO:0000305};AltName: Full=Oocyte binding/fusion factor {ECO:0000303|PubMed:15759005}; Short=OBF {ECO:0000303|PubMed:15759005};AltName: Full=Sperm-specific protein izumo {ECO:0000303|PubMed:15759005} | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
397
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:97563
Inoue N, et al., The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature. 2005 Mar 10;434(7030):234-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:144869 Inoue N, et al., Putative sperm fusion protein IZUMO and the role of N-glycosylation. Biochem Biophys Res Commun. 2008 Dec 19;377(3):910-4 J:155060 Ellerman DA, et al., Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm. Mol Reprod Dev. 2009 Dec;76(12):1188-99 J:160139 Inoue N, et al., Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse. PLoS One. 2010;5(4):e10301 J:209568 Bianchi E, et al., Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature. 2014 Apr 24;508(7497):483-7 J:228028 Inoue N, et al., Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice. Nat Commun. 2015;6:8858 J:235303 Ohto U, et al., Structure of IZUMO1-JUNO reveals sperm-oocyte recognition during mammalian fertilization. Nature. 2016 Jun 23;534(7608):566-9 J:258196 Young SA, et al., CRISPR/Cas9-mediated mutation revealed cytoplasmic tail is dispensable for IZUMO1 function and male fertility. Reproduction. 2016 Dec;152(6):665-672 J:278260 Inoue N, et al., Monitoring dimeric status of IZUMO1 during the acrosome reaction in living spermatozoon. Cell Cycle. 2018;17(11):1279-1285 J:289090 Lamas-Toranzo I, et al., TMEM95 is a sperm membrane protein essential for mammalian fertilization. Elife. 2020 Jun 2;9:e53913 J:289149 Noda T, et al., Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11493-11502 J:290694 Gaikwad AS, et al., GLIPR1L1 is an IZUMO-binding protein required for optimal fertilization in the mouse. BMC Biol. 2019 Oct 31;17(1):86 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 J:326368 Kaneda Y, et al., IRGC1, a testis-enriched immunity related GTPase, is important for fibrous sheath integrity and sperm motility in mice. Dev Biol. 2022 Aug;488:104-113 J:328498 Contreras W, et al., C11orf94/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly. Sci Adv. 2022 Aug 12;8(32):eabo6049 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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