Sequence Detail

ID/Version

Q9DBM0 Q8R543 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=ATP-binding cassette sub-family G member 8 {ECO:0000305}; EC=7.6.2.- {ECO:0000269|PubMed:16867993};AltName: Full=Sterolin-2 {ECO:0000303|PubMed:11452359, ECO:0000303|PubMed:11907139};

Provider

SWISS-PROT

Sequence

Polypeptide 673 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Abcg8	ATP binding cassette subfamily G member 8	46	99	3	8

Sequence references in MGI

J:72524 Lu K, et al., Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Am J Hum Genet. 2001 Aug;69(2):278-90
J:75695 Lu K, et al., Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8. J Lipid Res. 2002 Apr;43(4):565-78
J:80679 Yu L, et al., Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16237-42
J:86723 Graf GA, et al., ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. J Biol Chem. 2003 Nov 28;278(48):48275-82
J:94759 Klett EL, et al., A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol. BMC Med. 2004 Mar 24;2(1):5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:116923 Wang J, et al., Sterol transfer by ABCG5 and ABCG8: in vitro assay and reconstitution. J Biol Chem. 2006 Sep 22;281(38):27894-904
J:121052 Yu L, et al., Selective sterol accumulation in ABCG5/ABCG8-deficient mice. J Lipid Res. 2004 Feb;45(2):301-7
J:134560 Wang J, et al., Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8. Biochemistry. 2008 May 6;47(18):5194-204
J:215443 Wang J, et al., Relative roles of ABCG5/ABCG8 in liver and intestine. J Lipid Res. 2015 Feb;56(2):319-30
J:248556 Graf GA, et al., Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J Clin Invest. 2002 Sep;110(5):659-69