Sequence Detail

ID/Version

Q9DCN1 Q6PFA5 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=NAD-capped RNA hydrolase NUDT12 {ECO:0000305}; Short=DeNADding enzyme NUDT12 {ECO:0000305}; EC=3.6.1.- {ECO:0000269|PubMed:31101919, ECO:0000269|PubMed:32432673};AltName: Full=NADH pyrophosphatase NUDT12 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 462 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nudt12	nudix hydrolase 12	25	98	3	4

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:280091 Grudzien-Nogalska E, et al., Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. Nat Chem Biol. 2019 Jun;15(6):575-582
J:282288 Wu H, et al., Decapping Enzyme NUDT12 Partners with BLMH for Cytoplasmic Surveillance of NAD-Capped RNAs. Cell Rep. 2019 Dec 24;29(13):4422-4434.e13
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306601 Sharma S, et al., Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs. Nucleic Acids Res. 2020 Jul 9;48(12):6788-6798