Sequence Detail

ID/Version

Q9DCV3 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Diacylglycerol O-acyltransferase 2 {ECO:0000305}; EC=2.3.1.20 {ECO:0000269|PubMed:15834126, ECO:0000269|PubMed:16106050};AltName: Full=Acyl-CoA retinol O-fatty-acyltransferase; Short=ARAT; Short=Retinol O-fatty-acyltr

Provider

SWISS-PROT

Sequence

Polypeptide 388 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dgat2	diacylglycerol O-acyltransferase 2	58	107	3	12

Sequence references in MGI

J:72182 Cases S, et al., Cloning of dgat2, a second mammalian diacylglycerol acyltransferase, and related family members. J Biol Chem. 2001 Oct 19;276(42):38870-6
J:80036 Meegalla RL, et al., Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin. Biochem Biophys Res Commun. 2002 Nov 1;298(3):317-23
J:88742 Stone SJ, et al., Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J Biol Chem. 2004 Mar 19;279(12):11767-76
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101040 Yamazaki T, et al., Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1. J Biol Chem. 2005 Jun 3;280(22):21506-14
J:117609 Stone SJ, et al., Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2. J Biol Chem. 2006 Dec 29;281(52):40273-82
J:176988 McFie PJ, et al., Murine diacylglycerol acyltransferase-2 (DGAT2) can catalyze triacylglycerol synthesis and promote lipid droplet formation independent of its localization to the endoplasmic reticulum. J Biol Chem. 2011 Aug 12;286(32):28235-46
J:192630 Eichmann TO, et al., Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases. J Biol Chem. 2012 Nov 30;287(49):41446-57