Sequence Detail

ID/Version

Q9EPS3 Q99MM0 Q505E6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=D-glucuronyl C5-epimerase; EC=5.1.3.17 {ECO:0000269|PubMed:11279150, ECO:0000269|PubMed:16532012};AltName: Full=Heparan sulfate C5-epimerase; Short=Hsepi;AltName: Full=Heparin sulfate C5-epimerase;AltName: Full=Heparin/hepara

Provider

SWISS-PROT

Sequence

Polypeptide 618 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Glce	glucuronyl C5-epimerase	28	100	4	14

Sequence references in MGI

J:69858 Li JP, et al., Characterization of the D-glucuronyl C5-epimerase involved in the biosynthesis of heparin and heparan sulfate. J Biol Chem. 2001 Jun 8;276(23):20069-77
J:69930 Crawford BE, et al., Cloning, Golgi localization, and enzyme activity of the full-length heparin/heparan sulfate-glucuronic acid C5-epimerase. J Biol Chem. 2001 Jun 15;276(24):21538-43
J:84695 Li JP, et al., Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality. J Biol Chem. 2003 Aug 1;278(31):28363-6
J:160065 Reijmers RM, et al., Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase. J Immunol. 2010 Apr 1;184(7):3656-64
J:324199 Pinhal MA, et al., Enzyme interactions in heparan sulfate biosynthesis: uronosyl 5-epimerase and 2-O-sulfotransferase interact in vivo. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12984-9
J:349025 Feyerabend TB, et al., Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells. Nat Chem Biol. 2006 Apr;2(4):195-6