Sequence Detail

ID/Version

Q9EQ14 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Interleukin-23 subunit alpha; Short=IL-23 subunit alpha; Short=IL-23-A;AltName: Full=Interleukin-23 subunit p19; Short=IL-23p19;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 196 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il23a	interleukin 23, alpha subunit p19	58	97	2	54

Sequence references in MGI

J:65966 Oppmann B, et al., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000 Nov;13(5):715-25
J:73949 Cooper AM, et al., Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J Immunol. 2002 Feb 1;168(3):1322-7
J:88235 Ghilardi N, et al., Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J Immunol. 2004 Mar 1;172(5):2827-33
J:89968 Cua DJ, et al., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003 Feb 13;421(6924):744-8
J:107457 Happel KI, et al., Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med. 2005 Sep 19;202(6):761-9
J:108946 Yen D, et al., IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest. 2006 May;116(5):1310-6
J:111568 Langowski JL, et al., IL-23 promotes tumour incidence and growth. Nature. 2006 Jul 27;442(7101):461-5
J:122239 Kidoya H, et al., Fas ligand induces cell-autonomous IL-23 production in dendritic cells, a mechanism for Fas ligand-induced IL-17 production. J Immunol. 2005 Dec 15;175(12):8024-31
J:177824 Wiekowski MT, et al., Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death. J Immunol. 2001 Jun 15;166(12):7563-70
J:314396 Aggarwal S, et al., Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003 Jan 17;278(3):1910-4