Sequence Detail

ID/Version

Q9ERE7 Q91WK8 Q8C611 Q8CCX7 Q9CVB9 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=LRP chaperone MESD {ECO:0000305};AltName: Full=LDLR chaperone MESD;AltName: Full=Mesoderm development candidate 2;AltName: Full=Mesoderm development protein;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 224 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mesd	mesoderm development LRP chaperone	22	99	3	12

Sequence references in MGI

J:68210 Wines ME, et al., Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis. Genomics. 2001 Feb 15;72(1):88-98
J:82316 Hsieh JC, et al., Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell. 2003 Feb 7;112(3):355-67
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:175504 Chen J, et al., Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6. Structure. 2011 Mar 9;19(3):313-23
J:202742 Hoshi T, et al., Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes. FEBS Lett. 2013 Nov 29;587(23):3749-54
J:243458 Chen X, et al., Mesd extrinsically promotes phagocytosis by retinal pigment epithelial cells. Cell Biol Toxicol. 2016 Aug;32(4):347-58
J:245302 Collins MN, et al., Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type beta propeller domains. Structure. 2011 Mar 09;19(3):324-36
J:287028 Moosa S, et al., Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta. Am J Hum Genet. 2019 Oct 3;105(4):836-843
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89