Sequence Detail

ID/Version

Q9ERV1 Q6GTY9 Q9D0L9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=E3 ubiquitin-protein ligase makorin-2 {ECO:0000305}; EC=2.3.2.27 {ECO:0000269|PubMed:28378844};AltName: Full=RING-type E3 ubiquitin transferase makorin-2 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 416 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mkrn2	makorin, ring finger protein, 2	17	101	3	9

Sequence references in MGI

J:72223 Gray TA, et al., Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the raf1 proto-oncogene. Genomics. 2001 Oct;77(3):119-26
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:250191 Qian X, et al., Deficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility. Sci Rep. 2016 Dec 23;6:39318
J:274548 Shin C, et al., MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-kappaB and negatively regulates inflammatory responses. Sci Rep. 2017 Apr 5;7:46097
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89