Sequence Detail

ID/Version

Q9ES74 Q3UEV7 (UniProt | EBI)

Last sequence update: 2001-03-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase Nek7 {ECO:0000305}; EC=2.7.11.34 {ECO:0000250|UniProtKB:Q8TDX7};AltName: Full=Never in mitosis A-related kinase 7 {ECO:0000303|PubMed:10964517}; Short=NimA-related protein kinase 7 {ECO:0000303

Provider

SWISS-PROT

Sequence

Polypeptide 302 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nek7	NIMA (never in mitosis gene a)-related expressed kinase 7	54	105	3	40

Sequence references in MGI

J:58906 Kandli M, et al., Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics. 2000 Sep 1;68(2):187-96
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:168166 Salem H, et al., Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy. Oncogene. 2010 Jul 15;29(28):4046-57
J:226677 Shi H, et al., NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat Immunol. 2016 Mar;17(3):250-8
J:228574 Schmid-Burgk JL, et al., A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation. J Biol Chem. 2016 Jan 1;291(1):103-9
J:229240 He Y, et al., NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature. 2016 Feb 18;530(7590):354-7
J:277866 Ramachandran H, et al., Anks3 alters the sub-cellular localization of the Nek7 kinase. Biochem Biophys Res Commun. 2015 Aug 28;464(3):901-7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89