Sequence Detail

ID/Version

Q9JI78 Q8K113 Q9CTK3 (UniProt | EBI)

Last sequence update: 2006-09-05
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Short=PNGase; Short=mPNGase; EC=3.5.1.52;AltName: Full=N-glycanase 1;AltName: Full=Peptide:N-glycanase;

Provider

SWISS-PROT

Sequence

Polypeptide 651 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ngly1	N-glycanase 1	18	98	3	13

Sequence references in MGI

J:65050 Suzuki T, et al., PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase. J Cell Biol. 2000 May 29;149(5):1039-52
J:73568 Park H, et al., Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11163-8
J:82256 Hirsch C, et al., A role for N-glycanase in the cytosolic turnover of glycoproteins. EMBO J. 2003 Mar 3;22(5):1036-46
J:83338 Suzuki T, et al., Ngly1, a mouse gene encoding a deglycosylating enzyme implicated in proteasomal degradation: expression, genomic organization, and chromosomal mapping. Biochem Biophys Res Commun. 2003 May 2;304(2):326-32
J:92605 Katiyar S, et al., A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13774-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:102925 Li G, et al., Multiple modes of interaction of the deglycosylation enzyme, mouse peptide N-glycanase, with the proteasome. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):15809-14
J:106532 Katiyar S, et al., The retrotranslocation protein Derlin-1 binds peptide:N-glycanase to the endoplasmic reticulum. Mol Biol Cell. 2005 Oct;16(10):4584-94
J:113086 Zhao G, et al., Structure of the mouse peptide N-glycanase-HR23 complex suggests co-evolution of the endoplasmic reticulum-associated degradation and DNA repair pathways. J Biol Chem. 2006 May 12;281(19):13751-61
J:172993 Li G, et al., The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8348-53
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89