Sequence Detail

ID/Version

Q9JII6 Q9D012 Q9D0I7 Q9CQI5 Q9CQT8 Q9D0P3 Q9CT53 Q9D016 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Aldo-keto reductase family 1 member A1; EC=1.1.1.2 {ECO:0000269|PubMed:15769935, ECO:0000269|PubMed:20410296}; EC=1.1.1.372 {ECO:0000269|PubMed:22820017}; EC=1.1.1.54 {ECO:0000250|UniProtKB:P51635};AltName: Full=Alcoh

Provider

SWISS-PROT

Sequence

Polypeptide 325 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Akr1a1	aldo-keto reductase family 1, member A1	42	104	4	97

Sequence references in MGI

J:63126 Allan D, et al., Cloning and developmental expression of mouse aldehyde reductase (AKR1A4). Mech Dev. 2000 Jun;94(1-2):271-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100379 Barski OA, et al., Developmental expression and function of aldehyde reductase in proximal tubules of the kidney. Am J Physiol Renal Physiol. 2005 Jul;289(1):F200-7
J:164548 Gabbay KH, et al., Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis. J Biol Chem. 2010 Jun 18;285(25):19510-20
J:188043 Takahashi M, et al., In vivo role of aldehyde reductase. Biochim Biophys Acta. 2012 Nov;1820(11):1787-96
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:216934 Anand P, et al., Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation. Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18572-7
J:269368 Zhou HL, et al., Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury. Nature. 2019 Jan;565(7737):96-100
J:282972 Stomberski CT, et al., AKR1A1 is a novel mammalian S-nitroso-glutathione reductase. J Biol Chem. 2019 Nov 29;294(48):18285-18293
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89