Sequence Detail

ID/Version

Q9JIL4 Q9CQ72 Q8CDP5 Q8R4G2 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Short=NHERF-3;AltName: Full=CFTR-associated protein of 70 kDa;AltName: Full=Na(+)/H(+) exchanger regulatory factor 3;AltName: Full=Na/Pi cotransporter C-terminal-associated protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 519 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pdzk1	PDZ domain containing 1	20	103	4	17

Sequence references in MGI

J:74952 Gisler SM, et al., Interaction of the type IIa Na/Pi cotransporter with PDZ proteins. J Biol Chem. 2001 Mar 23;276(12):9206-13
J:81814 Kocher O, et al., Targeted Disruption of the PDZK1 Gene by Homologous Recombination. Mol Cell Biol. 2003 Feb;23(4):1175-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:101422 Thomson RB, et al., Role of PDZK1 in membrane expression of renal brush border ion exchangers. Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13331-6
J:114764 Gisler SM, et al., PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. Kidney Int. 2003 Nov;64(5):1733-45
J:150396 Kato Y, et al., PDZK1 directly regulates the function of organic cation/carnitine transporter OCTN2. Mol Pharmacol. 2005 Mar;67(3):734-43
J:166878 Kocher O, et al., In vitro and in vivo analysis of the binding of the C terminus of the HDL receptor scavenger receptor class B, type I (SR-BI), to the PDZ1 domain of its adaptor protein PDZK1. J Biol Chem. 2010 Nov 5;285(45):34999-5010
J:175397 Kocher O, et al., Identification of the PDZ3 domain of the adaptor protein PDZK1 as a second, physiologically functional binding site for the C terminus of the high density lipoprotein receptor scavenger receptor class B type I. J Biol Chem. 2011 Jul 15;286(28):25171-86
J:230388 Wang S, et al., Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activity. Cell. 2000 Sep 29;103(1):169-79
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89