Sequence Detail

ID/Version

Q9JJ28 Q8K095 Q8VI44 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Protein flightless-1 homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 1271 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Flii	flightless I actin binding protein	34	98	3	12

Sequence references in MGI

J:63555 Campbell HD, et al., Fliih, the murine homologue of the Drosophila melanogaster flightless I gene: nucleotide sequence, chromosomal mapping and overlap with Llglh. DNA Seq. 2000;11(1-2):29-40
J:76249 Campbell HD, et al., Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. Mol Cell Biol. 2002 May;22(10):3518-26
J:88187 Lee YH, et al., Developmentally essential protein flightless I is a nuclear receptor coactivator with actin binding activity. Mol Cell Biol. 2004 Mar;24(5):2103-17
J:182076 Kopecki Z, et al., Regulation of focal adhesions by flightless i involves inhibition of paxillin phosphorylation via a Rac1-dependent pathway. J Invest Dermatol. 2011 Jul;131(7):1450-9
J:187457 Mohammad I, et al., Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration. FASEB J. 2012 Aug;26(8):3260-72
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:347151 Kuwabara Y, et al., A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy. Proc Natl Acad Sci U S A. 2023 May 9;120(19):e2213696120
J:349401 Proszynski TJ, et al., Amotl2 interacts with LL5beta, localizes to podosomes and regulates postsynaptic differentiation in muscle. J Cell Sci. 2013 May 15;126(Pt 10):2225-35