Sequence Detail

ID/Version

Q9JJH7 Q3TU14 Q7TPL4 Q99NF9 A3KN89 Q9EPM4 Q9EPM3 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Transient receptor potential cation channel subfamily M member 5;AltName: Full=Long transient receptor potential channel 5; Short=LTrpC-5; Short=LTrpC5;AltName: Full=MLSN1- and TRP-related gene 1 protein;

Provider

SWISS-PROT

Sequence

Polypeptide 1158 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Trpm5	transient receptor potential cation channel, subfamily M, member 5	20	117	3	9

Sequence references in MGI

J:63552 Yatsuki H, et al., Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and human. DNA Res. 2000 Jun 30;7(3):195-206
J:63607 Enklaar T, et al., Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family. Genomics. 2000 Jul 15;67(2):179-87
J:63702 Paulsen M, et al., Sequence conservation and variability of imprinting in the beckwith-wiedemann syndrome gene cluster in human and mouse. Hum Mol Genet. 2000 Jul 22;9(12):1829-41
J:86984 Liu D, et al., Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15160-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:103852 Talavera K, et al., Heat activation of TRPM5 underlies thermal sensitivity of sweet taste. Nature. 2005 Dec 15;438(7070):1022-5
J:116742 Oike H, et al., Arachidonic acid can function as a signaling modulator by activating the TRPM5 cation channel in taste receptor cells. Biochim Biophys Acta. 2006 Sep;1761(9):1078-84
J:119745 Lin W, et al., Olfactory neurons expressing transient receptor potential channel M5 (TRPM5) are involved in sensing semiochemicals. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2471-6
J:121857 Zhang Z, et al., The transduction channel TRPM5 is gated by intracellular calcium in taste cells. J Neurosci. 2007 May 23;27(21):5777-86
J:122002 Damak S, et al., Trpm5 null mice respond to bitter, sweet, and umami compounds. Chem Senses. 2006 Mar;31(3):253-64
J:158750 Colsoul B, et al., Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5208-13
J:354157 Hofmann T, et al., TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr Biol. 2003 Jul 1;13(13):1153-8