Sequence Detail

ID/Version

Q9JK95 Q9JI77 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=p53 apoptosis effector related to PMP-22 {ECO:0000250|UniProtKB:Q96FX8};AltName: Full=Keratinocyte-associated protein 1 {ECO:0000250|UniProtKB:Q96FX8}; Short=KCP-1 {ECO:0000250|UniProtKB:Q96FX8};

Provider

SWISS-PROT

Sequence

Polypeptide 193 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Perp	PERP, TP53 apoptosis effector	21	112	3	8

Sequence references in MGI

J:67123 Attardi LD, et al., PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family. Genes Dev. 2000 Mar 15;14(6):704-18
J:97304 Ihrie RA, et al., Perp is a p63-regulated gene essential for epithelial integrity. Cell. 2005 Mar 25;120(6):843-56
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:126293 Ihrie RA, et al., Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes. Cell Death Differ. 2006 Sep;13(9):1614-8
J:182873 Jheon AH, et al., PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci. 2011 Mar 1;124(Pt 5):745-54
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:310979 Dusek RL, et al., Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer. Breast Cancer Res. 2012 Apr 20;14(2):R65
J:337641 Zhou Y, et al., Loss of Perp in T Cells Promotes Resistance to Apoptosis of T Helper 17 Cells and Exacerbates the Development of Experimental Autoimmune Encephalomyelitis in Mice. Front Immunol. 2018;9:842
J:347343 Hallstrom KN, et al., PERP, a host tetraspanning membrane protein, is required for Salmonella-induced inflammation. Cell Microbiol. 2015 Jun;17(6):843-59