Sequence Detail

ID/Version

Q9JKN6 Q8C8B9 (UniProt | EBI)

Last sequence update: 2007-01-09
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=RNA-binding protein Nova-1 {ECO:0000305};AltName: Full=Neuro-oncological ventral antigen 1;AltName: Full=Ventral neuron-specific protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 507 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nova1	NOVA alternative splicing regulator 1	26	103	4	12

Sequence references in MGI

J:60439 Ward-Bailey PF, et al., Neuromuscular ataxia: a new spontaneous mutation in the mouse. Mamm Genome. 2000 Oct;11(10):820-3
J:60771 Jensen KB, et al., Nova-1 regulates neuron-specific alternative splicing and is essential for neuronal viability. Neuron. 2000 Feb;25(2):359-71
J:62658 Polydorides AD, et al., A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6350-5
J:83959 Dredge BK, et al., Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. Mol Cell Biol. 2003 Jul;23(13):4687-700
J:98264 Dredge BK, et al., Nova autoregulation reveals dual functions in neuronal splicing. EMBO J. 2005 Apr 20;24(8):1608-20
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:273745 Saito Y, et al., Differential NOVA2-Mediated Splicing in Excitatory and Inhibitory Neurons Regulates Cortical Development and Cerebellar Function. Neuron. 2019 Feb 20;101(4):707-720.e5
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306578 Ule J, et al., An RNA map predicting Nova-dependent splicing regulation. Nature. 2006 Nov 30;444(7119):580-6
J:306636 Buckanovich RJ, et al., The neuronal RNA binding protein Nova-1 recognizes specific RNA targets in vitro and in vivo. Mol Cell Biol. 1997 Jun;17(6):3194-201
J:306711 Ule J, et al., CLIP identifies Nova-regulated RNA networks in the brain. Science. 2003 Nov 14;302(5648):1212-5
J:306713 Buckanovich RJ, et al., The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies. J Neurosci. 1996 Feb 1;16(3):1114-22