Sequence Detail

ID/Version

Q9JLY0 Q9D2A0 Q8VEN5 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Suppressor of cytokine signaling 6; Short=SOCS-6;AltName: Full=Cytokine-inducible SH2 protein 4; Short=CIS-4;AltName: Full=Suppressor of cytokine signaling 4; Short=SOCS-4;

Provider

SWISS-PROT

Sequence

Polypeptide 533 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Socs6	suppressor of cytokine signaling 6	15	100	3	17

Sequence references in MGI

J:77039 Krebs DL, et al., SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation. Mol Cell Biol. 2002 Jul;22(13):4567-78
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:177239 Vlacich G, et al., Pim3 negatively regulates glucose-stimulated insulin secretion. Islets. 2010 Sep-Oct;2(5):308-17
J:200291 Bayle J, et al., The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins. FEBS Lett. 2006 May 15;580(11):2609-14