ID/Version |
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Sequence description from provider |
RecName: Full=Piwi-like protein 1 {ECO:0000305}; EC=3.1.26.- {ECO:0000269|PubMed:22121019}; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
862
aa
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Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:71909
Kuramochi-Miyagawa S, et al., Two mouse piwi-related genes: miwi and mili. Mech Dev. 2001 Oct;108(1-2):121-33
J:77015 Deng W, et al., miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Dev Cell. 2002 Jun;2(6):819-30 J:110212 Grivna ST, et al., A novel class of small RNAs in mouse spermatogenic cells. Genes Dev. 2006 Jul 1;20(13):1709-14 J:110342 Kotaja N, et al., Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells. J Cell Sci. 2006 Jul 1;119(Pt 13):2819-25 J:112036 Costa Y, et al., Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006 Aug 1;15(15):2324-34 J:112901 Grivna ST, et al., MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13415-20 J:145879 Kimura M, et al., Characterization of Two Cytoplasmic Poly(A)-Binding Proteins, PABPC1 and PABPC2, in Mouse Spermatogenic Cells. Biol Reprod. 2009 Mar;80(3):545-54 J:148066 Girard A, et al., A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature. 2006 Jul 13;442(7099):199-202 J:151086 Vagin VV, et al., Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev. 2009 Aug 1;23(15):1749-62 J:152108 Reuter M, et al., Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile. Nat Struct Mol Biol. 2009 Jun;16(6):639-46 J:155574 Chen C, et al., Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20336-41 J:161125 Zheng K, et al., Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11841-6 J:182800 Reuter M, et al., Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Nature. 2011 Dec 8;480(7376):264-7 J:189932 Peruquetti RL, et al., Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS One. 2012;7(8):e42695 J:193401 Zhao S, et al., piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis. Dev Cell. 2013 Jan 14;24(1):13-25 J:197673 Saxe JP, et al., Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. EMBO J. 2013 Jul 3;32(13):1869-85 J:198228 Li XZ, et al., An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell. 2013 Apr 11;50(1):67-81 J:242565 Gou LT, et al., Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell. 2017 Jun 01;169(6):1090-1104.e13 J:243444 Tarabay Y, et al., Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression. J Cell Sci. 2017 Apr 15;130(8):1463-1474 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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