Sequence Detail

ID/Version

Q9JMB7 A1L324 Q6NXX0 A1L325 (UniProt | EBI)

Last sequence update: 2000-10-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Piwi-like protein 1 {ECO:0000305}; EC=3.1.26.- {ECO:0000269|PubMed:22121019};

Provider

SWISS-PROT

Sequence

Polypeptide 862 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Piwil1	piwi-like RNA-mediated gene silencing 1	51	117	3	12

Sequence references in MGI

J:71909 Kuramochi-Miyagawa S, et al., Two mouse piwi-related genes: miwi and mili. Mech Dev. 2001 Oct;108(1-2):121-33
J:77015 Deng W, et al., miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. Dev Cell. 2002 Jun;2(6):819-30
J:110212 Grivna ST, et al., A novel class of small RNAs in mouse spermatogenic cells. Genes Dev. 2006 Jul 1;20(13):1709-14
J:110342 Kotaja N, et al., Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells. J Cell Sci. 2006 Jul 1;119(Pt 13):2819-25
J:112036 Costa Y, et al., Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006 Aug 1;15(15):2324-34
J:112901 Grivna ST, et al., MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13415-20
J:145879 Kimura M, et al., Characterization of Two Cytoplasmic Poly(A)-Binding Proteins, PABPC1 and PABPC2, in Mouse Spermatogenic Cells. Biol Reprod. 2009 Mar;80(3):545-54
J:148066 Girard A, et al., A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature. 2006 Jul 13;442(7099):199-202
J:151086 Vagin VV, et al., Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev. 2009 Aug 1;23(15):1749-62
J:152108 Reuter M, et al., Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile. Nat Struct Mol Biol. 2009 Jun;16(6):639-46
J:155574 Chen C, et al., Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi. Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20336-41
J:161125 Zheng K, et al., Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11841-6
J:182800 Reuter M, et al., Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Nature. 2011 Dec 8;480(7376):264-7
J:189932 Peruquetti RL, et al., Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS One. 2012;7(8):e42695
J:193401 Zhao S, et al., piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis. Dev Cell. 2013 Jan 14;24(1):13-25
J:197673 Saxe JP, et al., Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline. EMBO J. 2013 Jul 3;32(13):1869-85
J:198228 Li XZ, et al., An ancient transcription factor initiates the burst of piRNA production during early meiosis in mouse testes. Mol Cell. 2013 Apr 11;50(1):67-81
J:242565 Gou LT, et al., Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell. 2017 Jun 01;169(6):1090-1104.e13
J:243444 Tarabay Y, et al., Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression. J Cell Sci. 2017 Apr 15;130(8):1463-1474
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89