Sequence Detail

ID/Version

Q9QUI0 O88336 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Transforming protein RhoA; EC=3.6.5.2 {ECO:0000269|PubMed:24352656};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 193 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Rhoa	ras homolog family member A	192	140	5	214

Sequence references in MGI

J:33389 Reid T, et al., Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. J Biol Chem. 1996 Jun 7;271(23):13556-60
J:41124 Watanabe N, et al., p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J. 1997 Jun 2;16(11):3044-56
J:46957 Alberts AS, et al., Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. J Biol Chem. 1998 Apr 10;273(15):8616-22
J:47658 Boettger-Tong HL, et al., Transposition of RhoA to the murine Y chromosome. Genomics. 1998 Apr 15;49(2):180-7
J:87273 Walther DJ, et al., Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release. Cell. 2003 Dec 26;115(7):851-62
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114700 van Horck FP, et al., Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. J Biol Chem. 2001 Feb 16;276(7):4948-56
J:169711 Wallace SW, et al., The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells. Mol Cell Biol. 2011 Jan;31(1):81-91
J:200496 Wu C, et al., Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis. J Biol Chem. 2011 Jul 1;286(26):23511-20
J:213034 Raynaud F, et al., Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis. J Biol Chem. 2014 Jan 31;289(5):2600-9
J:250125 Escamilla CO, et al., Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017 Nov 9;551(7679):227-231
J:260949 Suzuki JI, et al., Depletion of tumor suppressor Kank1 induces centrosomal amplification via hyperactivation of RhoA. Exp Cell Res. 2017 Apr 15;353(2):79-87
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:354373 Cachero TG, et al., The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel. Cell. 1998 Jun 12;93(6):1077-85