Sequence Detail

ID/Version

Q9QUJ0 Q9R1E7 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Hematopoietic cell signal transducer;AltName: Full=DNAX-activation protein 10;AltName: Full=Membrane protein DAP10;AltName: Full=Transmembrane adapter protein KAP10;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 79 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hcst	hematopoietic cell signal transducer	24	97	3	8

Sequence references in MGI

J:56494 Wu J, et al., An activating immunoreceptor complex formed by NKG2D and DAP10 [see comments]. Science. 1999 Jul 30;285(5428):730-2
J:69934 Chang C, et al., Cutting edge: KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties. J Immunol. 1999 Nov 1;163(9):4651-4
J:71139 Wilson MJ, et al., The mouse Dap10 gene. Immunogenetics. 2001 May-Jun;53(4):347-50
J:80426 Gilfillan S, et al., NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol. 2002 Dec;3(12):1150-5
J:92687 Rosen DB, et al., A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. J Immunol. 2004 Aug 15;173(4):2470-8
J:93939 Cella M, et al., Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity. J Exp Med. 2004 Sep 20;200(6):817-23
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100453 Ogasawara K, et al., Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts. Nat Immunol. 2005 Sep;6(9):938-45
J:138391 Graham DB, et al., Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics. J Immunol. 2006 Aug 15;177(4):2349-55
J:147155 Inui M, et al., Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4816-21
J:148086 Hyka-Nouspikel N, et al., Physiological roles of murine DAP10 adapter protein in tumor immunity and autoimmunity. Immunol Rev. 2006 Dec;214:106-17
J:148231 Hyka-Nouspikel N, et al., DAP10 deficiency breaks the immune tolerance against transplantable syngeneic melanoma. J Immunol. 2007 Sep 15;179(6):3763-71
J:219772 Diefenbach A, et al., Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol. 2002 Dec;3(12):1142-9