Sequence Detail

ID/Version

Q9QUK6 Q9D691 Q9QZF5 Q9Z203 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Toll-like receptor 4;AltName: CD_antigen=CD284;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 835 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tlr4	toll-like receptor 4	229	112	5	38

Sequence references in MGI

J:50273 Poltorak A, et al., Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis. 1998 Sep;24(3):340-55
J:51522 Poltorak A, et al., Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998 Dec 11;282(5396):2085-8
J:53343 Qureshi ST, et al., Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments]. J Exp Med. 1999 Feb 15;189(4):615-25
J:59320 Underhill DM, et al., The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens [see comments]. Nature. 1999 Oct 21;401(6755):811-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:127195 Kim HM, et al., Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell. 2007 Sep 7;130(5):906-17
J:137810 Kim F, et al., Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res. 2007 Jun 8;100(11):1589-96
J:158401 Stewart CR, et al., CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010 Feb;11(2):155-61
J:159190 Tsukamoto H, et al., Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. Int Immunol. 2010 Apr;22(4):271-80
J:184807 Ohto U, et al., Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7421-6
J:195394 Lu R, et al., CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PLoS Pathog. 2012;8(4):e1002597
J:205721 Sheedy FJ, et al., CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol. 2013 Aug;14(8):812-20
J:222669 Tanimura N, et al., The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane. Int Immunol. 2014 Jun;26(6):307-14
J:224712 Hu YH, et al., WDFY1 mediates TLR3/4 signaling by recruiting TRIF. EMBO Rep. 2015 Apr;16(4):447-55
J:224870 Heinz LX, et al., The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Rep. 2015 Jun 30;11(12):1919-28
J:244275 Luo L, et al., SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nat Commun. 2017 Jan 18;8:14133
J:289276 Sardinha-Silva A, et al., The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming. PLoS Pathog. 2019 Jun;15(6):e1007871
J:339920 Dang EV, et al., Secreted fungal virulence effector triggers allergic inflammation via TLR4. Nature. 2022 Aug;608(7921):161-167