Sequence Detail

ID/Version

Q9QUM4 Q9QXZ3 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Signaling lymphocytic activation molecule;AltName: Full=SLAM family member 1;AltName: CD_antigen=CD150;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 343 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slamf1	signaling lymphocytic activation molecule family member 1	58	97	2	14

Sequence references in MGI

J:50127 Sayos J, et al., The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM [see comments]. Nature. 1998 Oct 1;395(6701):462-9
J:58656 Castro AG, et al., Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells. J Immunol. 1999 Dec 1;163(11):5860-70
J:90484 Wang N, et al., The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions. J Exp Med. 2004 May 3;199(9):1255-64
J:93887 Cannons JL, et al., SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity. 2004 Nov;21(5):693-706
J:111421 Chen R, et al., Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor. Mol Cell Biol. 2006 Aug;26(15):5559-68
J:127620 Griewank K, et al., Homotypic interactions mediated by slamf1 and slamf6 receptors control NKT cell lineage development. Immunity. 2007 Nov;27(5):751-62
J:137438 Baev DV, et al., Impaired SLAM-SLAM homotypic interaction between invariant NKT cells and dendritic cells affects differentiation of IL-4/IL-10-secreting NKT2 cells in nonobese diabetic mice. J Immunol. 2008 Jul 15;181(2):869-77
J:144137 Wang N, et al., The costimulatory molecule SLAM is critical for pulmonary allergic responses. Am J Respir Cell Mol Biol. 2006 Aug;35(2):206-10
J:161614 Yusuf I, et al., Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol. 2010 Jul 1;185(1):190-202
J:164685 Berger SB, et al., SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol. 2010 Oct;11(10):920-7
J:185616 Ma C, et al., Receptor signaling lymphocyte-activation molecule family 1 (Slamf1) regulates membrane fusion and NADPH oxidase 2 (NOX2) activity by recruiting a Beclin-1/Vps34/ultraviolet radiation resistance-associated gene (UVRAG) complex. J Biol Chem. 2012 May 25;287(22):18359-65
J:227397 Latour S, et al., Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat Immunol. 2001 Aug;2(8):681-90
J:227465 Aversa G, et al., Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, cyclosporin A-sensitive T cell proliferation and IFN-gamma production. J Immunol. 1997 May 1;158(9):4036-44
J:244675 Wang N, et al., Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors. Front Immunol. 2015;6:158
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89