Sequence Detail

ID/Version

Q9QUN7 Q3U400 Q9DBC4 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Toll-like receptor 2;AltName: CD_antigen=CD282;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 784 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tlr2	toll-like receptor 2	141	119	3	24

Sequence references in MGI

J:55484 Heine H, et al., Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin. J Immunol. 1999 Jun 15;162(12):6971-5
J:59320 Underhill DM, et al., The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens [see comments]. Nature. 1999 Oct 21;401(6755):811-5
J:63906 Lin Y, et al., The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem. 2000 Aug 11;275(32):24255-63
J:82453 Ozinsky A, et al., The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13766-71
J:96018 Hoebe K, et al., CD36 is a sensor of diacylglycerides. Nature. 2005 Feb 3;433(7025):523-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:122395 Pathak SK, et al., Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. Nat Immunol. 2007 Jun;8(6):610-8
J:149492 Drage MG, et al., TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. Cell Immunol. 2009;258(1):29-37
J:156189 Kang JY, et al., Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity. 2009 Dec 18;31(6):873-84
J:158053 Jin MS, et al., Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell. 2007 Sep 21;130(6):1071-82
J:180787 Chen ST, et al., Recombinant MPT83 derived from Mycobacterium tuberculosis induces cytokine production and upregulates the function of mouse macrophages through TLR2. J Immunol. 2012 Jan 15;188(2):668-77
J:226711 Koymans KJ, et al., Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3). Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11018-23
J:248448 McKelvey AC, et al., RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity. Elife. 2016 Nov 2;5:e18496
J:289276 Sardinha-Silva A, et al., The lectin-specific activity of Toxoplasma gondii microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune priming. PLoS Pathog. 2019 Jun;15(6):e1007871