ID/Version |
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Sequence description from provider |
RecName: Full=Hairy/enhancer-of-split related with YRPW motif protein 2;AltName: Full=HES-related repressor protein 2;AltName: Full=Hairy and enhancer of split-related protein 2; Short=HESR-2;AltName: Full=Hairy-related transcription factor 2; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
339
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:53397
Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
J:58781 Nakagawa O, et al., HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments. Dev Biol. 1999 Dec 1;216(1):72-84 J:60859 Chin MT, et al., Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. J Biol Chem. 2000 Mar 3;275(9):6381-7 J:62860 Steidl C, et al., Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. Genomics. 2000 Jun 1;66(2):195-203 J:64398 Maier MM, et al., Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes. Biochem Biophys Res Commun. 2000 Aug 28;275(2):652-60 J:70797 Iso T, et al., HERP, a new primary target of Notch regulated by ligand binding. Mol Cell Biol. 2001 Sep;21(17):6071-9 J:74742 Iso T, et al., HERP1 is a cell type-specific primary target of Notch. J Biol Chem. 2002 Feb 22;277(8):6598-607 J:79024 Gessler M, et al., Mouse gridlock. No Aortic Coarctation or Deficiency, but Fatal Cardiac Defects in Hey2 -/- Mice. Curr Biol. 2002 Sep 17;12(18):1601 J:79025 Donovan J, et al., Tetralogy of fallot and other congenital heart defects in hey2 mutant mice. Curr Biol. 2002 Sep 17;12(18):1605 J:80681 Sakata Y, et al., Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16197-202 J:86573 Sakamoto M, et al., The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. J Biol Chem. 2003 Nov 7;278(45):44808-15 J:89444 Fischer A, et al., The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004 Apr 15;18(8):901-11 J:96337 Kokubo H, et al., Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. Dev Biol. 2005 Feb 15;278(2):301-9 J:97120 Kokubo H, et al., Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction. Circ Res. 2004 Sep 3;95(5):540-7 J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:101349 Fischer A, et al., Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol. 2005 Oct;25(20):8960-70 J:103925 Sakata Y, et al., Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle proliferation and migration in vitro. Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2069-74 J:109366 Satow T, et al., The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina. J Neurosci. 2001 Feb 15;21(4):1265-73 J:119923 Kokubo H, et al., Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2. Development. 2007 Feb;134(4):747-55 J:121581 Nakagawa O, et al., Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13655-60 J:133699 Fischer A, et al., Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res. 2007 Mar 30;100(6):856-63 J:133798 Koibuchi N, et al., CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression. Circ Res. 2007 Mar 30;100(6):850-5 J:175112 Iso T, et al., HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Mol Cell Biol. 2001 Sep;21(17):6080-9 J:175191 Kathiriya IS, et al., Hairy-related transcription factors inhibit GATA-dependent cardiac gene expression through a signal-responsive mechanism. J Biol Chem. 2004 Dec 24;279(52):54937-43 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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