Sequence Detail

ID/Version

Q9QY42 Q8C022 Q9Z0G3 Q8BXP9 Q8BKF8 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Prosaposin receptor GPR37;AltName: Full=G-protein coupled receptor 37;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 600 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gpr37	G protein-coupled receptor 37	43	105	4	13

Sequence references in MGI

J:45742 Marazziti D, et al., Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis. Genomics. 1998 NOV 1;53(3):315-324
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:236566 Yang HJ, et al., G protein-coupled receptor 37 is a negative regulator of oligodendrocyte differentiation and myelination. Nat Commun. 2016 Mar 10;7:10884
J:249772 Smith BM, et al., Mice lacking Gpr37 exhibit decreased expression of the myelin-associated glycoprotein MAG and increased susceptibility to demyelination. Neuroscience. 2017 Sep 1;358:49-57
J:264697 Bang S, et al., GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. J Clin Invest. 2018 Aug 1;128(8):3568-3582
J:303559 Bang S, et al., Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. Nat Commun. 2021 Mar 17;12(1):1704
J:312934 Qian Z, et al., Osteocalcin attenuates oligodendrocyte differentiation and myelination via GPR37 signaling in the mouse brain. Sci Adv. 2021 Oct 22;7(43):eabi5811
J:339578 Bhattacharya P, et al., Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling. Cell Rep. 2023 Jul 11;42(7):112808