Sequence Detail

ID/Version

Q9QY84 A2AMK4 Q9JMI5 Q9D9P4 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Actin-like protein 7A;AltName: Full=Actin-like-7-alpha;AltName: Full=Testis-specific actin-2; Short=T-actin-2;

Provider

SWISS-PROT

Sequence

Polypeptide 440 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Actl7a	actin-like 7a	32	96	2	3

Sequence references in MGI

J:56030 Chadwick BP, et al., Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31. Genomics. 1999 Jun 15;58(3):302-9
J:83114 Hisano M, et al., Genomic structure and promoter activity of the testis haploid germ cell-specific intronless genes, Tact1 and Tact2. Mol Reprod Dev. 2003 Jun;65(2):148-56
J:84562 Tanaka H, et al., Novel actin-like proteins T-ACTIN 1 and T-ACTIN 2 are differentially expressed in the cytoplasm and nucleus of mouse haploid germ cells. Biol Reprod. 2003 Aug;69(2):475-82
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:175315 Boeda B, et al., Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. J Biol Chem. 2011 Apr 1;286(13):11543-54
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:313844 Xin A, et al., Disruption in ACTL7A causes acrosomal ultrastructural defects in human and mouse sperm as a novel male factor inducing early embryonic arrest. Sci Adv. 2020 Aug;6(35):eaaz4796
J:337424 Ferrer P, et al., Testis-specific actin-like 7A (ACTL7A) is an indispensable protein for subacrosomal-associated F-actin formation, acrosomal anchoring, and male fertility. Mol Hum Reprod. 2023 Feb 28;29(3)
J:347872 Jin HJ, et al., Disruption in CYLC1 leads to acrosome detachment, sperm head deformity, and male in/subfertility in humans and mice. Elife. 2024 Apr 4;13
J:355632 Zhou X, et al., Actl7a deficiency in mice leads to male infertility and fertilization failure. Biochem Biophys Res Commun. 2022 Oct 1;623:154-161
J:355675 Zhang Y, et al., Loss of ACTL7A causes small head sperm by defective acrosome-acroplaxome-manchette complex. Reprod Biol Endocrinol. 2023 Sep 4;21(1):82