Sequence Detail

ID/Version

Q9QYS9 Q61110 Q78ZE4 Q78ZE5 Q8K4X9 Q8K4Y0 Q9R2A8 Q9Z246 Q9QUH4 Q9CW34 O88972 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=KH domain-containing RNA-binding protein QKI {ECO:0000305};AltName: Full=Protein quaking {ECO:0000303|PubMed:8589716}; Short=MqkI {ECO:0000312|MGI:MGI:97837};

Provider

SWISS-PROT

Sequence

Polypeptide 341 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Qki	quaking, KH domain containing RNA binding	79	115	5	46

Sequence references in MGI

J:31757 Ebersole TA, et al., The quaking gene product necessary in embryogenesis and myelination combines features of RNA binding and signal transduction proteins [see comments]. Nat Genet. 1996 Mar;12(3):260-5
J:37139 Hardy RJ, et al., Neural cell type-specific expression of QKI proteins is altered in quakingviable mutant mice. J Neurosci. 1996 Dec 15;16(24):7941-9
J:48638 Chen T, et al., Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization. Mol Cell Biol. 1998 Aug;18(8):4863-71
J:55007 Cox RD, et al., Contrasting effects of ENU induced embryonic lethal mutations of the quaking gene. Genomics. 1999 May 1;57(3):333-41
J:56070 Kondo T, et al., Genomic organization and expression analysis of the mouse qkI locus. Mamm Genome. 1999 Jul;10(7):662-9
J:63120 Li Z, et al., Destabilization and mislocalization of myelin basic protein mRNAs in quaking dysmyelination lacking the QKI RNA-binding proteins. J Neurosci. 2000 Jul 1;20(13):4944-53
J:75828 Noveroske JK, et al., Quaking is essential for blood vessel development. Genesis. 2002 Mar;32(3):218-30
J:80746 Larocque D, et al., Nuclear retention of MBP mRNAs in the quaking viable mice. Neuron. 2002 Dec 5;36(5):815-29
J:83008 Zhang Y, et al., Tyrosine phosphorylation of QKI mediates developmental signals to regulate mRNA metabolism. EMBO J. 2003 Apr 15;22(8):1801-10
J:84952 Lu Z, et al., The quakingviable mutation affects qkI mRNA expression specifically in myelin-producing cells of the nervous system. Nucleic Acids Res. 2003 Aug 1;31(15):4616-24
J:88215 Li Z, et al., Defective smooth muscle development in qkI-deficient mice. Dev Growth Differ. 2003 Oct-Dec;45(5-6):449-62
J:88351 Lorenzetti D, et al., The neurological mutant quaking(viable) is Parkin deficient. Mamm Genome. 2004 Mar;15(3):210-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:104981 Lu Z, et al., Developmental abnormalities of myelin basic protein expression in fyn knock-out brain reveal a role of Fyn in posttranscriptional regulation. J Biol Chem. 2005 Jan 7;280(1):389-95
J:106770 Bohnsack BL, et al., Visceral endoderm function is regulated by quaking and required for vascular development. Genesis. 2006 Feb;44(2):93-104
J:113665 Chen T, et al., Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain. Mol Cell Biol. 1997 Oct;17(10):5707-18
J:113965 Cote J, et al., Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell. 2003 Jan;14(1):274-87
J:166161 Zhao L, et al., Quaking I controls a unique cytoplasmic pathway that regulates alternative splicing of myelin-associated glycoprotein. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19061-6
J:171481 Zearfoss NR, et al., Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells. PLoS Genet. 2011;7(1):e1001269
J:219113 Wu J, et al., The quaking I-5 protein (QKI-5) has a novel nuclear localization signal and shuttles between the nucleus and the cytoplasm. J Biol Chem. 1999 Oct 8;274(41):29202-10
J:241657 Thangaraj MP, et al., RNA-binding Protein Quaking Stabilizes Sirt2 mRNA during Oligodendroglial Differentiation. J Biol Chem. 2017 Mar 31;292(13):5166-5182
J:253400 Fagg WS, et al., Autogenous cross-regulation of Quaking mRNA processing and translation balances Quaking functions in splicing and translation. Genes Dev. 2017 Sep 15;31(18):1894-1909
J:282964 Lu H, et al., QKI regulates adipose tissue metabolism by acting as a brake on thermogenesis and promoting obesity. EMBO Rep. 2020 Jan 7;21(1):e47929
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:300948 Chen X, et al., QKI is a critical pre-mRNA alternative splicing regulator of cardiac myofibrillogenesis and contractile function. Nat Commun. 2021 Jan 4;12(1):89
J:303832 Sakers K, et al., Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain. Nat Commun. 2021 Mar 9;12(1):1537
J:304686 Lee J, et al., QUAKING Regulates Microexon Alternative Splicing of the Rho GTPase Pathway and Controls Microglia Homeostasis. Cell Rep. 2020 Dec 29;33(13):108560
J:306332 Shin S, et al., Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Nat Commun. 2021 May 21;12(1):3005
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:308836 Ren J, et al., Qki is an essential regulator of microglial phagocytosis in demyelination. J Exp Med. 2021 Jan 4;218(1)
J:327565 Zhou X, et al., Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis. Elife. 2021 May 4;10:e60467
J:335878 Montanes-Agudo P, et al., The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes. Cardiovasc Res. 2023 May 22;119(5):1161-1174
J:338015 Montanes-Agudo P, et al., Quaking regulates circular RNA production in cardiomyocytes. J Cell Sci. 2023 Jul 1;136(13)
J:341407 Zhai D, et al., QKI degradation in macrophage by RNF6 protects mice from MRSA infection via enhancing PI3K p110beta dependent autophagy. Cell Biosci. 2022 Sep 10;12(1):154
J:341410 Yang C, et al., Targeting QKI-7 in vivo restores endothelial cell function in diabetes. Nat Commun. 2020 Jul 30;11(1):3812