Sequence Detail

ID/Version

Q9QZF2 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Glypican-1;Contains: RecName: Full=Secreted glypican-1;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 557 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gpc1	glypican 1	37	105	4	8

Sequence references in MGI

J:98747 Cappai R, et al., The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo. J Biol Chem. 2005 Apr 8;280(14):13913-20
J:112079 Cheng F, et al., Copper-dependent co-internalization of the prion protein and glypican-1. J Neurochem. 2006 Sep;98(5):1445-57
J:159598 Jen YH, et al., Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis. Neural Dev. 2009;4:33
J:161728 Gutierrez J, et al., A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation. Mol Cell Biol. 2010 Apr;30(7):1634-49
J:186130 Whipple CA, et al., A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis. Oncogene. 2012 May 17;31(20):2535-44
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89