Sequence Detail

ID/Version

Q9QZL0 G3X8V8 Q3U3Z9 Q8K2Y2 (UniProt | EBI)

Last sequence update: 2014-02-19
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Receptor-interacting serine/threonine-protein kinase 3 {ECO:0000303|PubMed:19590578}; EC=2.7.11.1 {ECO:0000269|PubMed:10490590, ECO:0000269|PubMed:24095729, ECO:0000269|PubMed:32200799, ECO:0000269|PubMed:32296175};AltName: Full=RIP-

Provider

SWISS-PROT

Sequence

Polypeptide 486 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ripk3	receptor-interacting serine-threonine kinase 3	98	114	3	32

Sequence references in MGI

J:57772 Pazdernik NJ, et al., Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB. Mol Cell Biol. 1999 Oct;19(10):6500-8
J:87683 Newton K, et al., Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol Cell Biol. 2004 Feb;24(4):1464-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:157332 Rebsamen M, et al., DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep. 2009 Aug;10(8):916-22
J:199609 Chen W, et al., Diverse sequence determinants control human and mouse receptor interacting protein 3 (RIP3) and mixed lineage kinase domain-like (MLKL) interaction in necroptotic signaling. J Biol Chem. 2013 Jun 7;288(23):16247-61
J:201938 Sun L, et al., Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012 Jan 20;148(1-2):213-27
J:204592 Xie T, et al., Structural insights into RIP3-mediated necroptotic signaling. Cell Rep. 2013 Oct 17;5(1):70-8
J:204620 Murphy JM, et al., The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity. 2013 Sep 19;39(3):443-53
J:204906 Kaiser WJ, et al., Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem. 2013 Oct 25;288(43):31268-79
J:209137 Newton K, et al., Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 2014 Mar 21;343(6177):1357-60
J:214393 Dillon CP, et al., RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell. 2014 May 22;157(5):1189-202
J:214394 Rickard JA, et al., RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell. 2014 May 22;157(5):1175-88
J:242990 Newton K, et al., RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016 Dec 01;540(7631):129-133
J:242991 Lin J, et al., RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016 Dec 01;540(7631):124-128
J:251915 Geng J, et al., Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nat Commun. 2017 Aug 25;8(1):359
J:263339 Choi SW, et al., PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Mol Cell. 2018 Jun 7;70(5):920-935.e7
J:279203 Daniels BP, et al., The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. Immunity. 2019 Jan 15;50(1):64-76.e4
J:279494 Tang Y, et al., K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. Nat Commun. 2019 Sep 13;10(1):4157
J:289066 Upton JW, et al., DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA. Cell Host Microbe. 2012 Mar 15;11(3):290-7
J:289082 Zhang T, et al., Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. Cell. 2020 Mar 19;180(6):1115-1129.e13
J:289088 Nogusa S, et al., RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus. Cell Host Microbe. 2016 Jul 13;20(1):13-24
J:289096 Thapa RJ, et al., DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death. Cell Host Microbe. 2016 Nov 9;20(5):674-681
J:289444 Sridharan H, et al., Murine cytomegalovirus IE3-dependent transcription is required for DAI/ZBP1-mediated necroptosis. EMBO Rep. 2017 Aug;18(8):1429-1441
J:289452 Jiao H, et al., Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature. 2020 Apr;580(7803):391-395
J:290369 Kuriakose T, et al., ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. Sci Immunol. 2016 Aug 5;1(2)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87