Sequence Detail

ID/Version

Q9QZS0 Q61430 Q61435 Q8CCD6 (UniProt | EBI)

Last sequence update: 2007-03-06
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Collagen alpha-3(IV) chain;Contains: RecName: Full=Tumstatin;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1669 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Col4a3	collagen, type IV, alpha 3	32	108	3	15

Sequence references in MGI

J:21122 Miner JH, et al., Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches. J Cell Biol. 1994 Nov;127(3):879-91
J:37963 Cosgrove D, et al., Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome. Genes Dev. 1996 Dec 1;10(23):2981-92
J:58257 Lu W, et al., Insertional mutation of the collagen genes Col4a3 and Col4a4 in a mouse model of Alport syndrome. Genomics. 1999 Oct 15;61(2):113-24
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120382 Hamano Y, et al., Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell. 2003 Jun;3(6):589-601
J:120399 Miyoshi T, et al., Tumor-specific expression of the RGD-alpha3(IV)NC1 domain suppresses endothelial tube formation and tumor growth in mice. FASEB J. 2006 Sep;20(11):1904-6