Sequence Detail

ID/Version

Q9QZS8 A2AK84 Q9JME1 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=SH2 domain-containing protein 3C;AltName: Full=Cas/HEF1-associated signal transducer;AltName: Full=SH2 domain-containing Eph receptor-binding protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 854 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sh2d3c	SH2 domain containing 3C	11	96	4	8

Sequence references in MGI

J:58260 Dodelet VC, et al., A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. J Biol Chem. 1999 Nov 5;274(45):31941-6
J:60858 Sakakibara A, et al., Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. J Biol Chem. 2000 Mar 3;275(9):6404-10
J:93464 Dail M, et al., SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases. J Biol Chem. 2004 Nov 1;279(40):41892-902
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:116755 Regelmann AG, et al., The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking. Immunity. 2006 Dec;25(6):907-18
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:161448 Al-Shami A, et al., The adaptor protein Sh2d3c is critical for marginal zone B cell development and function. J Immunol. 2010 Jul 1;185(1):327-34
J:164874 Wang L, et al., The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain. J Neurosci. 2010 Sep 29;30(39):13201-10
J:166239 Browne CD, et al., SHEP1 partners with CasL to promote marginal zone B-cell maturation. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18944-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89