Sequence Detail

ID/Version

Q9R001 B2RRX9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 5; Short=ADAM-TS 5; Short=ADAM-TS5; Short=ADAMTS-5; EC=3.4.24.-;AltName: Full=ADMP-2;AltName: Full=Aggrecanase-2;AltName: Full=Implantin;Flags: Pr

Provider

SWISS-PROT

Sequence

Polypeptide 930 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adamts5	ADAM metallopeptidase with thrombospondin type 1 motif 5	30	123	2	17

Sequence references in MGI

J:57247 Hurskainen TL, et al., ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999 Sep 3;274(36):25555-63
J:105138 Stanton H, et al., ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature. 2005 Mar 31;434(7033):648-52
J:239748 McMahon M, et al., ADAMTS5 Is a Critical Regulator of Virus-Specific T Cell Immunity. PLoS Biol. 2016 Nov;14(11):e1002580
J:262354 Bauters D, et al., Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling. Mol Metab. 2017 Jul;6(7):715-724
J:302455 Stupka N, et al., Versican processing by a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats proteinases-5 and -15 facilitates myoblast fusion. J Biol Chem. 2013 Jan 18;288(3):1907-17