Sequence Detail

ID/Version

Q9R002 Q7TMN6 E9QLD9 Q8VEL7 Q38JF1 P15091 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Interferon-activable protein 202 {ECO:0000303|PubMed:10493828}; Short=Ifi-202 {ECO:0000303|PubMed:10493828};AltName: Full=Interferon-inducible protein p202 {ECO:0000303|PubMed:2477366};AltName: Full=Lupus susceptibility protein p202

Provider

SWISS-PROT

Sequence

Polypeptide 445 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ifi202a	interferon activated gene 202A	10	0	0	1
Gene	Ifi202b	interferon activated gene 202B	1	100	0	8

Sequence references in MGI

J:10055 Choubey D, et al., Interferons as gene activators. Indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1. J Biol Chem. 1989 Oct 15;264(29):17182-9
J:17917 Choubey D, et al., Interferon action: cytoplasmic and nuclear localization of the interferon-inducible 52-kD protein that is encoded by the Ifi 200 gene from the gene 200 cluster. J Interferon Res. 1993 Feb;13(1):43-52
J:31083 Min W, et al., The interferon-inducible p202 protein as a modulator of transcription: inhibition of NF-kappa B, c-Fos, and c-Jun activities. Mol Cell Biol. 1996 Jan;16(1):359-68
J:36914 Datta B, et al., p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. J Biol Chem. 1996 Nov 1;271(44):27544-55
J:57929 Wang H, et al., Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster. Genomics. 1999 Sep 15;60(3):281-94
J:89510 Pramanik R, et al., Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility. J Biol Chem. 2004 Apr 16;279(16):16121-7
J:123266 Rozzo SJ, et al., Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity. 2001 Sep;15(3):435-43
J:131681 Xin H, et al., Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. J Immunol. 2006 May 15;176(10):5863-70
J:187571 Roberts TL, et al., HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science. 2009 Feb 20;323(5917):1057-60
J:205029 Ru H, et al., Structural basis for termination of AIM2-mediated signaling by p202. Cell Res. 2013 Jun;23(6):855-8
J:332982 Yin Q, et al., Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation. Cell Rep. 2013 Jul 25;4(2):327-39
J:333978 Li H, et al., Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling. Acta Crystallogr F Struct Biol Commun. 2014 Jan;70(Pt 1):21-9
J:334010 Koul D, et al., p202 self-associates through a sequence conserved among the members of the 200-family proteins. FEBS Lett. 1998 Oct 30;438(1-2):21-4