Sequence Detail

ID/Version

Q9R0E1 Q9CYY9 Q542E0 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3;Includes: RecName: Full=Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3; EC=1.14.11.4 {ECO:0000269|PubMed:16447251, ECO:0000269|PubMed:16467571}; AltNam

Provider

SWISS-PROT

Sequence

Polypeptide 741 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	53	102	3	11

Sequence references in MGI

J:56595 Ruotsalainen H, et al., Characterization of cDNAs for mouse lysyl hydroxylase 1, 2 and 3, their phylogenetic analysis and tissue-specific expression in the mouse. Matrix Biol. 1999 Jun;18(3):325-9
J:74018 Ruotsalainen H, et al., Complete genomic structure of mouse lysyl hydroxylase 2 and lysyl hydroxylase 3/collagen glucosyltransferase. Matrix Biol. 2001 Apr;20(2):137-46
J:93434 Rautavuoma K, et al., Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice. Proc Natl Acad Sci U S A. 2004 Oct 28;101(39):14120-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:106510 Ruotsalainen H, et al., Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes. J Cell Sci. 2006 Feb 15;119(Pt 4):625-35
J:128353 Sipila L, et al., Secretion and assembly of type IV and VI collagens depend on glycosylation of hydroxylysines. J Biol Chem. 2007 Nov 16;282(46):33381-8
J:170651 Sricholpech M, et al., Lysyl hydroxylase 3 glucosylates galactosylhydroxylysine residues in type I collagen in osteoblast culture. J Biol Chem. 2011 Mar 18;286(11):8846-56
J:195451 Ruotsalainen H, et al., The activities of lysyl hydroxylase 3 (LH3) regulate the amount and oligomerization status of adiponectin. PLoS One. 2012;7(11):e50045
J:225284 Risteli M, et al., Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin. PLoS One. 2014;9(11):e113498
J:265634 Salo AM, et al., Lysyl hydroxylase 3 (LH3) modifies proteins in the extracellular space, a novel mechanism for matrix remodeling. J Cell Physiol. 2006 Jun;207(3):644-53
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89