Sequence Detail

ID/Version

Q9R0K7 O88863 (UniProt | EBI)

Last sequence update: 2001-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Plasma membrane calcium-transporting ATPase 2; Short=PMCA2; EC=7.2.2.10 {ECO:0000269|PubMed:17234811};AltName: Full=Plasma membrane calcium ATPase isoform 2;AltName: Full=Plasma membrane calcium pump isoform 2;

Provider

SWISS-PROT

Sequence

Polypeptide 1198 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	104	104	3	25

Sequence references in MGI

J:48863 Kozel PJ, et al., Balance and hearing deficits in mice with a null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2. J Biol Chem. 1998 Jul 24;273(30):18693-6
J:48969 Street VA, et al., Mutations in a plasma membrane Ca2+-ATPase gene cause deafness in deafwaddler mice. Nat Genet. 1998 Aug;19(4):390-4
J:93962 Reinhardt TA, et al., Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk. J Biol Chem. 2004 Oct 8;279(41):42369-73
J:102783 Ueno T, et al., A mouse with a point mutation in plasma membrane Ca2+-ATPase isoform 2 gene showed the reduced Ca2+ influx in cerebellar neurons. Neurosci Res. 2002 Apr;42(4):287-97
J:119503 Ficarella R, et al., A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness. Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1516-21
J:121220 Empson RM, et al., Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse. J Neurosci. 2007 Apr 4;27(14):3753-8
J:176779 Empson RM, et al., Reduced expression of the Ca(2+) transporter protein PMCA2 slows Ca(2+) dynamics in mouse cerebellar Purkinje neurones and alters the precision of motor coordination. J Physiol. 2010 Mar 15;588(Pt 6):907-22
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89