Sequence Detail

ID/Version

Q9R0N3 Q7TQG8 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Synaptotagmin-11 {ECO:0000305};AltName: Full=Synaptotagmin XI {ECO:0000303|PubMed:23303671}; Short=SytXI;

Provider

SWISS-PROT

Sequence

Polypeptide 430 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Syt11	synaptotagmin XI	104	99	4	18

Sequence references in MGI

J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:193251 Arango Duque G, et al., Synaptotagmin XI Regulates Phagocytosis and Cytokine Secretion in Macrophages. J Immunol. 2013 Feb 15;190(4):1737-45
J:211330 Milochau A, et al., Synaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic beta-cells. FEBS Lett. 2014 Jun 27;588(14):2217-22
J:233974 Sreetama SC, et al., Injured astrocytes are repaired by Synaptotagmin XI-regulated lysosome exocytosis. Cell Death Differ. 2016 Apr;23(4):596-607
J:239895 Bento CF, et al., The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nat Commun. 2016 Jun 09;7:11803
J:244524 Du C, et al., Synaptotagmin-11 inhibits cytokine secretion and phagocytosis in microglia. Glia. 2017 Oct;65(10):1656-1667
J:260099 Wang C, et al., Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology. Nat Commun. 2018 Jan 8;9(1):81
J:274868 Shimojo M, et al., Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity. Genes Dev. 2019 Mar 1;33(5-6):365-376
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89