Sequence Detail

ID/Version

Q9R0P9 Q9R122 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Ubiquitin carboxyl-terminal hydrolase isozyme L1; Short=UCH-L1; EC=3.4.19.12 {ECO:0000269|PubMed:12913066, ECO:0000269|PubMed:32494592};AltName: Full=Neuron cytoplasmic protein 9.5;AltName: Full=PGP 9.5; Short=PGP9.5;

Provider

SWISS-PROT

Sequence

Polypeptide 223 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Uchl1	ubiquitin carboxy-terminal hydrolase L1	50	176	3	16

Sequence references in MGI

J:57318 Saigoh K, et al., Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice [see comments]. Nat Genet. 1999 Sep;23(1):47-51
J:81158 Marzban G, et al., Age-related alterations in the protein expression profile of C57BL/6J mouse pituitaries. Exp Gerontol. 2002 Dec;37(12):1451-60
J:85069 Osaka H, et al., Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet. 2003 Aug 15;12(16):1945-58
J:88434 Harada T, et al., Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo. Am J Pathol. 2004 Jan;164(1):59-64
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:279966 Reinicke AT, et al., Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules. J Immunol. 2019 Oct 1;203(7):1730-1742
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296972 Gao H, et al., UCHL1 regulates oxidative activity in skeletal muscle. PLoS One. 2020;15(11):e0241716