Sequence Detail

ID/Version

Q9R171 P28655 Q9QVT5 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Cerebellin-1;AltName: Full=Brain protein D3;AltName: Full=Precerebellin;Contains: RecName: Full=Cerebellin; Short=CER;Contains: RecName: Full=[des-Ser1]-cerebellin; Short=des-Ser1-cerebellin;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 193 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cbln1	cerebellin 1 precursor protein	43	125	3	9

Sequence references in MGI

J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
J:21224 Kavety B, et al., Genomic structure and mapping of precerebellin and a precerebellin-related gene. Brain Res Mol Brain Res. 1994 Nov;27(1):152-6
J:51554 Kavety B, et al., Characterization of transcript processing of the gene encoding precerebellin-1. Brain Res Mol Brain Res. 1998 Dec 10;63(1):98-104
J:64199 Pang Z, et al., Cbln3, a novel member of the precerebellin family that binds specifically to cbln1. J Neurosci. 2000 Sep 1;20(17):6333-9
J:102281 Bao D, et al., The structure and proteolytic processing of Cbln1 complexes. J Neurochem. 2005 Nov;95(3):618-29
J:102516 Hirai H, et al., Cbln1 is essential for synaptic integrity and plasticity in the cerebellum. Nat Neurosci. 2005 Nov;8(11):1534-41
J:112922 Miura E, et al., Distinct expression of Cbln family mRNAs in developing and adult mouse brains. Eur J Neurosci. 2006 Aug;24(3):750-60
J:117650 Bao D, et al., Cbln1 is essential for interaction-dependent secretion of Cbln3. Mol Cell Biol. 2006 Dec;26(24):9327-37
J:119795 Iijima T, et al., Characterization of a transneuronal cytokine family Cbln--regulation of secretion by heteromeric assembly. Eur J Neurosci. 2007 Feb;25(4):1049-57
J:146470 Matsuda K, et al., Cbln1 binds to specific postsynaptic sites at parallel fiber-Purkinje cell synapses in the cerebellum. Eur J Neurosci. 2009 Feb;29(4):707-17
J:159100 Matsuda K, et al., Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer. Science. 2010 Apr 16;328(5976):363-8
J:177327 Matsuda K, et al., Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions. Eur J Neurosci. 2011 Apr;33(8):1447-61
J:184952 Wei P, et al., The Cbln family of proteins interact with multiple signaling pathways. J Neurochem. 2012 Jun;121(5):717-29
J:196989 Ito-Ishida A, et al., Presynaptically released Cbln1 induces dynamic axonal structural changes by interacting with GluD2 during cerebellar synapse formation. Neuron. 2012 Nov 8;76(3):549-64
J:228490 Ito-Ishida A, et al., Cbln1 downregulates the formation and function of inhibitory synapses in mouse cerebellar Purkinje cells. Eur J Neurosci. 2014 Apr;39(8):1268-80
J:261984 Seigneur E, et al., Genetic Ablation of All Cerebellins Reveals Synapse Organizer Functions in Multiple Regions Throughout the Brain. J Neurosci. 2018 May 16;38(20):4774-4790
J:263439 Deans MR, et al., Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1. PLoS One. 2010 Sep 15;5(9):e12765
J:269669 Rong Y, et al., Glycosylation of Cblns attenuates their receptor binding. Brain Res. 2018 Sep 1;1694:129-139
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89