ID/Version |
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Sequence description from provider |
RecName: Full=Angiopoietin-related protein 3;AltName: Full=Angiopoietin-like protein 3;Contains: RecName: Full=ANGPTL3(17-224);Flags: Precursor; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
455
aa
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Source | |||||||||||||||
Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:60238
Conklin D, et al., Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics. 1999 Dec 15;62(3):477-82
J:75358 Koishi R, et al., Angptl3 regulates lipid metabolism in mice. Nat Genet. 2002 Feb;30(2):151-7 J:84022 Ando Y, et al., A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice. J Lipid Res. 2003 Jun;44(6):1216-23 J:86130 Ono M, et al., Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. J Biol Chem. 2003 Oct 24;278(43):41804-9 J:92089 Shimamura M, et al., Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor. Biochem Biophys Res Commun. 2004 Sep 24;322(3):1080-1085 J:103363 Koster A, et al., Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology. 2005 Nov;146(11):4943-50 J:107479 Fujimoto K, et al., Angptl3-null mice show low plasma lipid concentrations by enhanced lipoprotein lipase activity. Exp Anim. 2006 Jan;55(1):27-34 J:129942 Jin W, et al., Hepatic proprotein convertases modulate HDL metabolism. Cell Metab. 2007 Aug;6(2):129-36 J:131463 Shimamura M, et al., Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):366-72 J:168414 Zheng J, et al., Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche. Blood. 2011 Jan 13;117(2):470-9 J:203527 Essalmani R, et al., Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J Biol Chem. 2013 Sep 13;288(37):26410-8 J:224940 Wang Y, et al., Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion. J Lipid Res. 2015 Jul;56(7):1296-307 J:226803 Wang Y, et al., Hepatic ANGPTL3 regulates adipose tissue energy homeostasis. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11630-5 J:244720 Liu J, et al., A novel role of angiopoietin-like-3 associated with podocyte injury. Pediatr Res. 2015 Jun;77(6):732-9 J:251991 Kim HK, et al., Regulation of energy balance by the hypothalamic lipoprotein lipase regulator Angptl3. Diabetes. 2015 Apr;64(4):1142-53 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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