Sequence Detail

ID/Version

Q9R182 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Angiopoietin-related protein 3;AltName: Full=Angiopoietin-like protein 3;Contains: RecName: Full=ANGPTL3(17-224);Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 455 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Angptl3	angiopoietin-like 3	62	101	3	22

Sequence references in MGI

J:60238 Conklin D, et al., Identification of a mammalian angiopoietin-related protein expressed specifically in liver. Genomics. 1999 Dec 15;62(3):477-82
J:75358 Koishi R, et al., Angptl3 regulates lipid metabolism in mice. Nat Genet. 2002 Feb;30(2):151-7
J:84022 Ando Y, et al., A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice. J Lipid Res. 2003 Jun;44(6):1216-23
J:86130 Ono M, et al., Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. J Biol Chem. 2003 Oct 24;278(43):41804-9
J:92089 Shimamura M, et al., Leptin and insulin down-regulate angiopoietin-like protein 3, a plasma triglyceride-increasing factor. Biochem Biophys Res Commun. 2004 Sep 24;322(3):1080-1085
J:103363 Koster A, et al., Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology. 2005 Nov;146(11):4943-50
J:107479 Fujimoto K, et al., Angptl3-null mice show low plasma lipid concentrations by enhanced lipoprotein lipase activity. Exp Anim. 2006 Jan;55(1):27-34
J:129942 Jin W, et al., Hepatic proprotein convertases modulate HDL metabolism. Cell Metab. 2007 Aug;6(2):129-36
J:131463 Shimamura M, et al., Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):366-72
J:168414 Zheng J, et al., Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche. Blood. 2011 Jan 13;117(2):470-9
J:203527 Essalmani R, et al., Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J Biol Chem. 2013 Sep 13;288(37):26410-8
J:224940 Wang Y, et al., Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion. J Lipid Res. 2015 Jul;56(7):1296-307
J:226803 Wang Y, et al., Hepatic ANGPTL3 regulates adipose tissue energy homeostasis. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11630-5
J:244720 Liu J, et al., A novel role of angiopoietin-like-3 associated with podocyte injury. Pediatr Res. 2015 Jun;77(6):732-9
J:251991 Kim HK, et al., Regulation of energy balance by the hypothalamic lipoprotein lipase regulator Angptl3. Diabetes. 2015 Apr;64(4):1142-53