Sequence Detail

ID/Version

Q9R1E0 Q9JJW4 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Forkhead box protein O1;AltName: Full=Forkhead box protein O1A;AltName: Full=Forkhead in rhabdomyosarcoma;

Provider

SWISS-PROT

Sequence

Polypeptide 652 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Foxo1	forkhead box O1	118	142	4	37

Sequence references in MGI

J:64810 Nakae J, et al., Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem. 1999 Jun 4;274(23):15982-5
J:79560 Nakae J, et al., Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1. Nat Genet. 2002 Oct;32(2):245-53
J:92247 Furuyama T, et al., Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem. 2004 Aug 13;279(33):34741-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114687 Cooper MP, et al., Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev. 2006 Nov 1;20(21):2996-3009
J:117723 Qiao L, et al., SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. J Biol Chem. 2006 Dec 29;281(52):39915-24
J:124079 Sekine K, et al., Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development. EMBO J. 2007 Aug 8;26(15):3607-15
J:129943 Jing E, et al., SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab. 2007 Aug;6(2):105-14
J:156956 Di Pietro N, et al., Serum- and glucocorticoid-inducible kinase 1 (SGK1) regulates adipocyte differentiation via forkhead box O1. Mol Endocrinol. 2010 Feb;24(2):370-80
J:160665 Puigserver P, et al., Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003 May 29;423(6939):550-5
J:163084 Goitre L, et al., KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PLoS One. 2010;5(7):e11786
J:170486 Zhou Y, et al., Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med. 2011 Mar;17(3):356-65
J:178279 Daitoku H, et al., Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10042-7
J:183276 Kode A, et al., FoxO1 protein cooperates with ATF4 protein in osteoblasts to control glucose homeostasis. J Biol Chem. 2012 Mar 16;287(12):8757-68
J:184684 Nakae J, et al., Novel repressor regulates insulin sensitivity through interaction with Foxo1. EMBO J. 2012 May 16;31(10):2275-95
J:185464 Yan L, et al., The B55alpha-containing PP2A holoenzyme dephosphorylates FOXO1 in islet beta-cells under oxidative stress. Biochem J. 2012 Jun 1;444(2):239-47
J:186018 Yang S, et al., Foxo1 mediates insulin-like growth factor 1 (IGF1)/insulin regulation of osteocalcin expression by antagonizing Runx2 in osteoblasts. J Biol Chem. 2011 May 27;286(21):19149-58
J:187559 Hughes KJ, et al., FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide. J Biol Chem. 2011 Mar 11;286(10):8338-48
J:209483 Wang F, et al., SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma. Mol Biol Cell. 2009 Feb;20(3):801-8
J:212254 Zhang P, et al., Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10684-9
J:225490 Fritzius T, et al., Akt- and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. EMBO J. 2008 May 7;27(9):1399-410
J:242722 Ekim Ustunel B, et al., Control of diabetic hyperglycaemia and insulin resistance through TSC22D4. Nat Commun. 2016 Nov 09;7:13267
J:245577 Tong X, et al., DDB1-Mediated CRY1 Degradation Promotes FOXO1-Driven Gluconeogenesis in Liver. Diabetes. 2017 Oct;66(10):2571-2582
J:254113 Song MY, et al., Insulin secretion impairment in Sirt6 knockout pancreatic beta cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway. Sci Rep. 2016 Jul 26;6:30321
J:281991 Jung SM, et al., Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1. Mol Cell. 2019 Aug 22;75(4):807-822.e8
J:287060 van Gastel N, et al., Lipid availability determines fate of skeletal progenitor cells via SOX9. Nature. 2020 Mar;579(7797):111-117
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:320480 Wang L, et al., TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver. Cell Metab. 2022 Jan 4;34(1):158-170.e5