Sequence Detail

ID/Version

Q9R210 (UniProt | EBI)

Last sequence update: 2001-08-29
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Transcription factor EB {ECO:0000303|PubMed:10036191};

Provider

SWISS-PROT

Sequence

Polypeptide 475 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tfeb	transcription factor EB	47	120	3	74

Sequence references in MGI

J:50513 Steingrimsson E, et al., The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. Development. 1998 Dec;125(23):4607-16
J:53287 Rehli M, et al., Cloning and characterization of the murine genes for bHLH-ZIP transcription factors TFEC and TFEB reveal a common gene organization for all MiT subfamily members. Genomics. 1999 Feb 15;56(1):111-20
J:112628 Huan C, et al., Transcription factors TFE3 and TFEB are critical for CD40 ligand expression and thymus-dependent humoral immunity. Nat Immunol. 2006 Oct;7(10):1082-1091
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:182149 Settembre C, et al., A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J. 2012 Mar 7;31(5):1095-108
J:233673 Najibi M, et al., An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense. Cell Rep. 2016 May 24;15(8):1728-42
J:239895 Bento CF, et al., The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway. Nat Commun. 2016 Jun 09;7:11803
J:274781 Willett R, et al., TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes. Nat Commun. 2017 Nov 17;8(1):1580
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:296987 Napolitano G, et al., A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dube syndrome. Nature. 2020 Sep;585(7826):597-602
J:342735 Zhang Z, et al., Itaconate is a lysosomal inducer that promotes antibacterial innate immunity. Mol Cell. 2022 Aug 4;82(15):2844-2857.e10