Sequence Detail

ID/Version

Q9WTK0 Q9D756 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Nuclear protein 1 {ECO:0000305};AltName: Full=Protein p8 {ECO:0000303|Ref.1};

Provider

SWISS-PROT

Sequence

Polypeptide 80 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nupr1	nuclear protein transcription regulator 1	83	111	4	19

Sequence references in MGI

J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:133728 Vasseur S, et al., p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis. Oncogene. 2002 Mar 7;21(11):1685-94
J:140899 Million Passe CM, et al., Loss of the protein NUPR1 (p8) leads to delayed LHB expression, delayed ovarian maturation, and testicular development of a sertoli-cell-only syndrome-like phenotype in mice. Biol Reprod. 2008 Oct;79(4):598-607
J:153063 Sambasivan R, et al., The small chromatin-binding protein p8 coordinates the association of anti-proliferative and pro-myogenic proteins at the myogenin promoter. J Cell Sci. 2009 Oct 1;122(Pt 19):3481-91
J:156137 Plant SR, et al., Upregulation of the stress-associated gene p8 in mouse models of demyelination and in multiple sclerosis tissues. Glia. 2006 Apr 1;53(5):529-37
J:188293 Hamidi T, et al., Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. J Clin Invest. 2012 Jun 1;122(6):2092-103
J:203693 Barbosa-Sampaio HC, et al., Nupr1 deletion protects against glucose intolerance by increasing beta cell mass. Diabetologia. 2013 Nov;56(11):2477-86
J:271708 Galichon P, et al., Stress Response Gene Nupr1 Alleviates Cyclosporin A Nephrotoxicity In Vivo. J Am Soc Nephrol. 2017 Feb;28(2):545-556
J:271800 Kong DK, et al., Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. Mol Biol Cell. 2010 Apr 15;21(8):1335-49