Sequence Detail

ID/Version

Q9WTR6 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Cystine/glutamate transporter {ECO:0000305};AltName: Full=Amino acid transport system xc-;AltName: Full=Solute carrier family 7 member 11;AltName: Full=Subtle gray protein {ECO:0000305|PubMed:16037214};AltName: Full=xCT;

Provider

SWISS-PROT

Sequence

Polypeptide 502 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc7a11	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	61	106	3	15

Sequence references in MGI

J:54626 Sato H, et al., Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. J Biol Chem. 1999 Apr 23;274(17):11455-8
J:100476 Chintala S, et al., Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10964-9
J:102902 Sato H, et al., Redox imbalance in cystine/glutamate transporter-deficient mice. J Biol Chem. 2005 Nov 11;280(45):37423-9
J:113249 Shih AY, et al., Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation. J Neurosci. 2006 Oct 11;26(41):10514-23
J:121453 Sakakura Y, et al., Expression and function of cystine/glutamate transporter in neutrophils. J Leukoc Biol. 2007 Apr;81(4):974-82
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:293326 Martis RM, et al., Mapping of the cystine-glutamate exchanger in the mouse eye: a role for xCT in controlling extracellular redox balance. Histochem Cell Biol. 2019 Oct;152(4):293-310