Sequence Detail

ID/Version

Q9WV60 (UniProt | EBI)

Last sequence update: 2000-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Glycogen synthase kinase-3 beta; Short=GSK-3 beta; EC=2.7.11.26 {ECO:0000250|UniProtKB:P49841};AltName: Full=Serine/threonine-protein kinase GSK3B; EC=2.7.11.1 {ECO:0000269|PubMed:22539723, ECO:0000269|PubMed:23542741

Provider

SWISS-PROT

Sequence

Polypeptide 420 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gsk3b	glycogen synthase kinase 3 beta	293	159	4	124

Sequence references in MGI

J:63274 Hoeflich KP, et al., Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation [see comments]. Nature. 2000 Jul 6;406(6791):86-90
J:98263 McManus EJ, et al., Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis. EMBO J. 2005 Apr 20;24(8):1571-83
J:115106 Beaulieu JM, et al., An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell. 2005 Jul 29;122(2):261-73
J:121428 Garrido JJ, et al., GSK3 alpha and GSK3 beta are necessary for axon formation. FEBS Lett. 2007 Apr 17;581(8):1579-86
J:135659 Tanabe K, et al., Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. PLoS Biol. 2008 Feb;6(2):e37
J:147568 Mao Y, et al., Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 2009 Mar 20;136(6):1017-31
J:148434 Chen T, et al., Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling. J Biol Chem. 2009 Mar 13;284(11):6683-9
J:157250 Sahar S, et al., Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One. 2010;5(1):e8561
J:161722 Kurabayashi N, et al., DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. Mol Cell Biol. 2010 Apr;30(7):1757-68
J:170927 Wu X, et al., Skin stem cells orchestrate directional migration by regulating microtubule-ACF7 connections through GSK3beta. Cell. 2011 Feb 4;144(3):341-52
J:180612 Wakatsuki S, et al., ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation. Nat Cell Biol. 2011 Dec;13(12):1415-23
J:183987 Lin SY, et al., GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy. Science. 2012 Apr 27;336(6080):477-81
J:196439 Chen BB, et al., A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nat Immunol. 2013 May;14(5):470-9
J:198048 Kaasik K, et al., Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock. Cell Metab. 2013 Feb 5;17(2):291-302
J:201566 Maurer U, et al., Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell. 2006 Mar 17;21(6):749-60
J:242722 Ekim Ustunel B, et al., Control of diabetic hyperglycaemia and insulin resistance through TSC22D4. Nat Commun. 2016 Nov 09;7:13267
J:255973 Qie S, et al., Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma. Nat Commun. 2017 Nov 16;8(1):1534
J:272534 Lu Y, et al., Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK. Oncotarget. 2017 Aug 15;8(33):54913-54924
J:273508 Besing RC, et al., GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity. Hippocampus. 2017 Aug;27(8):890-898
J:274568 Choi JH, et al., LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. Science. 2019 May 10;364(6440)
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:332980 Del'Guidice T, et al., FXR1P is a GSK3beta substrate regulating mood and emotion processing. Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4610-9
J:333976 Brethour D, et al., A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition. Sci Rep. 2017 Jan 18;7:40313