Sequence Detail

ID/Version

Q9WV93 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Hairy/enhancer-of-split related with YRPW motif protein 1;AltName: Full=Hairy and enhancer of split-related protein 1; Short=HESR-1;AltName: Full=Hairy-related transcription factor 1; Short=HRT-1; Short=mHRT1;

Provider

SWISS-PROT

Sequence

Polypeptide 299 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hey1	hairy/enhancer-of-split related with YRPW motif 1	91	153	3	6

Sequence references in MGI

J:53397 Leimeister C, et al., Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis. Mech Dev. 1999 Jul;85(1-2):173-7
J:56103 Kokubo H, et al., Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split. Biochem Biophys Res Commun. 1999 Jul 5;260(2):459-65
J:62860 Steidl C, et al., Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. Genomics. 2000 Jun 1;66(2):195-203
J:64398 Maier MM, et al., Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes. Biochem Biophys Res Commun. 2000 Aug 28;275(2):652-60
J:70797 Iso T, et al., HERP, a new primary target of Notch regulated by ligand binding. Mol Cell Biol. 2001 Sep;21(17):6071-9
J:74742 Iso T, et al., HERP1 is a cell type-specific primary target of Notch. J Biol Chem. 2002 Feb 22;277(8):6598-607
J:86573 Sakamoto M, et al., The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. J Biol Chem. 2003 Nov 7;278(45):44808-15
J:89444 Fischer A, et al., The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev. 2004 Apr 15;18(8):901-11
J:96337 Kokubo H, et al., Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system. Dev Biol. 2005 Feb 15;278(2):301-9
J:101349 Fischer A, et al., Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol. 2005 Oct;25(20):8960-70
J:109366 Satow T, et al., The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina. J Neurosci. 2001 Feb 15;21(4):1265-73
J:119923 Kokubo H, et al., Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2. Development. 2007 Feb;134(4):747-55
J:121581 Nakagawa O, et al., Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13655-60
J:133699 Fischer A, et al., Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res. 2007 Mar 30;100(6):856-63
J:139632 Van Wayenbergh R, et al., Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse. Dev Dyn. 2003 Dec;228(4):716-25
J:175112 Iso T, et al., HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling. Mol Cell Biol. 2001 Sep;21(17):6080-9