Sequence Detail

ID/Version

Q9WVL4 (UniProt | EBI)

Last sequence update: 1999-11-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Rhodopsin kinase GRK1; Short=RK; EC=2.7.11.14 {ECO:0000269|PubMed:10097103};AltName: Full=G protein-coupled receptor kinase 1 {ECO:0000312|MGI:MGI:1345146};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 564 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Grk1	G protein-coupled receptor kinase 1	23	98	3	7

Sequence references in MGI

J:54021 Chen CK, et al., Abnormal photoresponses and light-induced apoptosis in rods lacking rhodopsin kinase. Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):3718-22
J:60964 Lyubarsky AL, et al., Mice lacking G-protein receptor kinase 1 have profoundly slowed recovery of cone-driven retinal responses. J Neurosci. 2000 Mar 15;20(6):2209-17
J:101051 Strissel KJ, et al., Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors. J Biol Chem. 2005 Aug 12;280(32):29250-5
J:173491 Osawa S, et al., Phosphorylation of G Protein-coupled Receptor Kinase 1 (GRK1) Is Regulated by Light but Independent of Phototransduction in Rod Photoreceptors. J Biol Chem. 2011 Jun 10;286(23):20923-9
J:241495 Charette JR, et al., A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects. Adv Exp Med Biol. 2016;854:177-83