Sequence Detail

ID/Version

Q9Z0D9 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=CX3C chemokine receptor 1 {ECO:0000303|PubMed:9918795}; Short=C-X3-C CKR-1 {ECO:0000303|PubMed:9918795}; Short=CX3CR1 {ECO:0000303|PubMed:9918795}; Short=mCX3CR1 {ECO:0000303|PubMed:9918795};AltName: Full=Fractalkine

Provider

SWISS-PROT

Sequence

Polypeptide 354 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cx3cr1	C-X3-C motif chemokine receptor 1	95	110	3	28

Sequence references in MGI

J:51793 Combadiere C, et al., Gene cloning, RNA distribution, and functional expression of mCX3CR1, a mouse chemotactic receptor for the CX3C chemokine fractalkine. Biochem Biophys Res Commun. 1998 Dec 30;253(3):728-32
J:81822 Lesnik P, et al., Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis. J Clin Invest. 2003 Feb;111(3):333-40
J:82033 Haskell CA, et al., Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection. J Clin Invest. 2001 Sep;108(5):679-88
J:84544 Jung S, et al., Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol. 2000 Jun;20(11):4106-14
J:90912 Geissmann F, et al., Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003 Jul;19(1):71-82
J:95694 Niess JH, et al., CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 2005 Jan 14;307(5707):254-8
J:110266 Cardona AE, et al., Control of microglial neurotoxicity by the fractalkine receptor. Nat Neurosci. 2006 Jul;9(7):917-24
J:129712 Huang D, et al., The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J. 2006 May;20(7):896-905
J:132951 Lu P, et al., Protective Roles of the Fractalkine/CX3CL1-CX3CR1 Interactions in Alkali-Induced Corneal Neovascularization through Enhanced Antiangiogenic Factor Expression. J Immunol. 2008 Mar 15;180(6):4283-91
J:145036 Landsman L, et al., CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood. 2009 Jan 22;113(4):963-72
J:166138 Mionnet C, et al., CX3CR1 is required for airway inflammation by promoting T helper cell survival and maintenance in inflamed lung. Nat Med. 2010 Nov;16(11):1305-12
J:175794 Paolicelli RC, et al., Synaptic pruning by microglia is necessary for normal brain development. Science. 2011 Sep 9;333(6048):1456-8
J:211924 Zhan Y, et al., Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat Neurosci. 2014 Mar;17(3):400-6
J:255660 Leonardi I, et al., CX3CR1(+) mononuclear phagocytes control immunity to intestinal fungi. Science. 2018 Jan 12;359(6372):232-236
J:263697 Haskell CA, et al., Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation. J Biol Chem. 1999 Apr 9;274(15):10053-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306002 Doron I, et al., Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies. Cell. 2021 Feb 18;184(4):1017-1031.e14