Sequence Detail

ID/Version

Q9Z0E3 Q9JLW5 Q9JLX0 Q9JLW8 Q9JLW1 Q9JLW3 Q9JLW7 Q9JLW0 Q9JLW2 Q9JLW9 Q9JLW4 Q9JLW6 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Autoimmune regulator;AltName: Full=Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; Short=APECED protein homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 552 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Aire	autoimmune regulator	44	127	3	36

Sequence references in MGI

J:53032 Mittaz L, et al., Isolation and characterization of the mouse Aire gene. Biochem Biophys Res Commun. 1999 Feb 16;255(2):483-90
J:53196 Blechschmidt K, et al., The mouse Aire gene: comparative genomic sequencing, gene organization, and expression. Genome Res. 1999 Feb;9(2):158-66
J:53197 Wang CY, et al., Cloning of Aire, the mouse homologue of the autoimmune regulator (AIRE) gene responsible for autoimmune polyglandular syndrome type 1 (ASP1). Genomics. 1999 Feb 1;55(3):322-6
J:59587 Shi JD, et al., Chromosomal localization and complete genomic sequence of the murine autoimmune regulator gene (Aire). Autoimmunity. 1999;31(1):47-53
J:68936 Halonen M, et al., Subcellular location and expression pattern of autoimmune regulator (Aire), the mouse orthologue for human gene defective in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED). J Histochem Cytochem. 2001 Feb;49(2):197-208
J:141379 Yano M, et al., Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J Exp Med. 2008 Nov 24;205(12):2827-38
J:157503 Laan M, et al., Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J Immunol. 2009 Dec 15;183(12):7682-91
J:176844 Lei Y, et al., Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med. 2011 Feb 14;208(2):383-94
J:177171 Kumar PG, et al., The autoimmune regulator (AIRE) is a DNA-binding protein. J Biol Chem. 2001 Nov 2;276(44):41357-64
J:208220 Gardner JM, et al., Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4(+) T cells. Immunity. 2013 Sep 19;39(3):560-72