Sequence Detail

ID/Version

Q9Z0E6 Q4FK03 Q8CIC6 Q9R1I0 Q921N2 (UniProt | EBI)

Last sequence update: 1999-05-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Guanylate-binding protein 2; EC=3.6.5.- {ECO:0000250|UniProtKB:P32456};AltName: Full=GTP-binding protein 2; Short=GBP-2; Short=mGBP-2; Short=mGBP2;AltName: Full=Guanine nucleotide-binding protein 2;AltName: Fu

Provider

SWISS-PROT

Sequence

Polypeptide 589 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gbp2	guanylate binding protein 2	67	98	6	11

Sequence references in MGI

J:51786 Vestal DJ, et al., Murine GBP-2: a new IFN-gamma-induced member of the GBP family of GTPases isolated from macrophages. J Interferon Cytokine Res. 1998 Nov;18(11):977-85
J:55832 Anderson SL, et al., Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family. J Interferon Cytokine Res. 1999 May;19(5):487-94
J:64689 Boehm U, et al., Two families of GTPases dominate the complex cellular response to IFN-gamma. J Immunol. 1998 Dec 15;161(12):6715-23
J:155210 Degrandi D, et al., Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol. 2007 Dec 1;179(11):7729-40
J:208845 Pilla DM, et al., Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6046-51
J:210626 Meunier E, et al., Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature. 2014 May 15;509(7500):366-70
J:231713 Meunier E, et al., Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida. Nat Immunol. 2015 May;16(5):476-84
J:231714 Man SM, et al., The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection. Nat Immunol. 2015 May;16(5):467-75
J:236523 Man SM, et al., IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes. Cell. 2016 Oct 6;167(2):382-396.e17
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:314959 Steffens N, et al., Essential Role of mGBP7 for Survival of Toxoplasma gondii Infection. mBio. 2020 Jan 21;11(1)
J:333172 Balakrishnan A, et al., Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa. Cell Death Discov. 2018;4:3