Sequence Detail

ID/Version

Q9Z0F8 Q505A7 O88726 Q9Z0K3 Q9R1U4 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Disintegrin and metalloproteinase domain-containing protein 17; Short=ADAM 17; EC=3.4.24.86 {ECO:0000250|UniProtKB:P78536};AltName: Full=TNF-alpha convertase;AltName: Full=TNF-alpha-converting enzyme;AltName: CD_antigen=CD156

Provider

SWISS-PROT

Sequence

Polypeptide 827 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Adam17	a disintegrin and metallopeptidase domain 17	104	118	4	35

Sequence references in MGI

J:53171 Amour A, et al., TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3. FEBS Lett. 1998 Sep 11;435(1):39-44
J:56250 Mizui Y, et al., cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter. Gene. 1999 Jun 11;233(1-2):67-74
J:57143 Cerretti DP, et al., Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25. Cytokine. 1999 Aug;11(8):541-51
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:273527 Li N, et al., Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J. 2007 Jan 24;26(2):494-504
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89